Intal refers to the anti-allergic anti-anti-asthmatics. The active ingredient of this drug is cromolyn sodium. The systematic use of it leads to a reduction in the symptoms of allergic inflammation of the respiratory system. Sodium cromoglycate inhibits anadroll both early and late stages of allergic reactions by inhibiting mast cell degranulation and release of these inflammatory mediators (histamine, bradykinin, substance medlennoreagiruyuschey, leukotrienes, prostaglandins). Because of these properties Intal prevents bronchospasm caused by contact with an allergen or other precipitating factor (cold air, physical exertion, stress). In addition, it can reduce the use of other anti-asthmatics (bronchodilators, corticosteroids). Effect of the drug develops gradually. After 4-6 weeks of INTA decreases the frequency of asthma attacks. Treatment should be long. When you remove the drug possible resumption of asthma attacks. For treatment of acute attacks of the drug is not used asthma. Sodium cromoglycate anadroll is not metabolised. Excreted by the kidneys and bile in approximately equal amounts in unchanged form. The rest of the drug is excreted from the lungs with a current of exhaled air or deposited on the walls of the oropharynx and then swallowed (without significant absorption – less than 2%) and excreted from the body through the digestive tract.
Precautions should be used drug for the treatment of patients with impaired renal function and anadroll liver. Treatment should be under constant medical supervision (it is advisable to reduce the dose).
Pregnancy and lactation
The drug should not be administered to women in the first 3 months of pregnancy.
Cromolyn sodium can be assigned to a doctor only when the expected benefit to pregnant or nursing anadroll women are greater than the potential risk to the fetus or infant.
Dosage and method of administration Adults (including the elderly) and children On 2 inhalations 4 times a day. When you reach the optimal therapeutic effect can go on a maintenance dose (1 inhalation 4 times a day), providing optimum control of the disease. In severe cases, as well as the largest concentration of allergens, the dose can be increased to two inhalations 6-8 times a day. After a therapeutic effect should not suddenly discontinue use of INTA. If necessary, the abolition of the drug produced gradually over weeks. During dose reduction possible resumption of symptoms. Supplementing the drug can be produced immediately before exercise to prevent asthma physical effort or prior to contact with the alleged allergens. If concomitant anadroll therapy with bronchodilators need to be taken before the inhalation of Intal. Patients receiving corticosteroids, the addition of Intan may allow significantly reduce the dose or completely reject them. The basis of effective treatment is a proper use of the inhaler.Using an inhaler children it is recommended only under adult supervision.
The use of an inhaler
The first time you should shake anadroll the inhaler and click once or twice on the metering valve.
Inhalation should adhere to the following instructions:
Remove the dust cap. Inspect the inner and outer surfaces of the mouthpiece (tip) to ensure that they are clean.
Vigorously shake the inhaler.
Hold the inhaler upright, placing your thumb on the base of the can.
Make the most of the full exhale, then insert the mouthpiece into the mouth between the teeth (but not biting it) and firmly grasp the lips.
since inhale air through your mouth, press the base of the cartridge so that the spray dose INTA; at the same time keep a calm and deep breath in.
Hold your breath, remove the inhaler from the mouth. Continue to hold back your breath as much as possible.
If you want to immediately enter the second dose of Intal, repeat the procedure.
After inhalation always close the mouthpiece dust cap.
The drug can cause irritation of the anadroll upper respiratory tract, dryness in the mouth, unpleasant taste, hoarseness, cough, intermittent bronchospasm. In the case of recurring bronchospasm make pre-bronchodilator, cough and soothe the water intake immediately after inhalation.
As with every inhalation therapy immediately after inhalation may suddenly develop bronchospasm. In this case, you should stop taking the drug and to appoint the patient more treatment.
The above-mentioned adverse events can be reduced by the joint application of INTA with a spacer.
The rare adverse events include: anaphylaxis (difficulty in swallowing, hives, itchy skin, swelling of the face, lips and eyelids, expressed crowing, or shortness of breath, decreased blood pressure), headache and dizziness, painful or difficult urination, frequent urination, nausea, and rash.
After discontinuation of the drug may increase asthma, eosinophilic infiltration of the lung.
Very rarely observed cases of eosinophilic pneumonia.
An overdose of
sodium cromoglycate has a low toxicity, therefore the risk of overdose and the development of any toxic effects small.
Interaction with other drugs
Beta adrenostimulyatorov, glucocorticosteroids (GCS), antihistamine drugs and theophylline enhance the effect.
Combined designation sodium cromoglycate and corticosteroids can reduce the dose of the latter, and in some cases eliminate them.
Bronchodilators should be taken (inhaled) before inhalation of the drug .
for relief of bronchospasm drug is not used.
If concomitant therapy with bronchodilators need to be taken before the inhalation of INTA.
The maintenance dose of corticosteroids anadroll is usually possible to reduce, and in some cases, completely abolished. During reduction of glucocorticosteroids dose the patient should be under close medical supervision: the rate of dose reduction should not exceed 10% per week. In the event of eosinophilic pneumonia receiving the drug should be discontinued.
aerosol for inhalation dose of 5 mg / dose.
The amount of drug in the dose equal to 112 aluminum aerosol bottle placed in a dispensing device with a plastic dust cover. According to the cylinder 1 together with instructions for use, or 1 cylinder with an additional metering device and instructions for use in a cardboard box.
The temperature is not above 30 ° C. Protect from direct sunlight. Do not store in the refrigerator and do not freeze.
Keep out of the reach of children.
Do not use beyond the expiration date printed on the package.